Save the date: 4th IRN i-GPCRnet meeting from July 8th to 10th, 2024 in Nottingham

Save the date: 4th IRN i-GPCRnet meeting from July 8th to 10th, 2024 in Nottingham


To register for the meeting please click here.

 

4th IRN i-GPCRnet Annual Meeting Programme

4th IRN i-GPCRnet Annual Meeting Programme

 

Day 1 – Monday 8th of July 2024

12:00   Opening and registration

14:15   Introduction

 

Session 1:

14:30   Carsten Hoffmann (Institute for Molecular Cell Biology, CMB – Center for Molecular Biomedicine, University Clinic Jena, Jena, Germany):
“Novel insights into GPCR regulation by using GRK-KO cells”

15:15   Maria Tindara Ignazzitto (Barcelona, Spain):
“Photoswitching azobenzenes to reversibly control β-adrenergic receptors with light”

15:30   Yair Ben-Chaim (Ra’anana, Israel):
“Voltage dependence of G protein coupled receptors”

15:45   Laura Klement (Jena, Germany):
“Targeting cellular kinases to prevent Influenza A virus infection utilizing encapsulated
kinase inhibitors”

16:00   Coffee break

16:30   Promega (sponsor talk)

16:45   Cyril Goudet (Montpellier, France):
“Optical control of adenosine A2A receptor using istradefylline photosensitivity”

17:00   Amod Godbole (Jena, Germany):
“The molecular basis for GRK/arrestin-mediated regulation of adenosine A1 receptor”

17:15   Ana Novak (Orléans, France):
“Identification and characterization of nanobodies targeting serotonin 5-HT7 receptor
for application in GPCR Drug Discovery”

17:30   Chris Tate (MRC Laboratory of Molecular Biology, Cambridge, United Kingdom):
“GPCR dimerisation: insights from cryo-EM structures of the yeast pheromone receptor Ste2”

18:15   Poster session and dinner

 

Day 2 – Tuesday 9th of July 2024

Session 2:

09:00   Andrea Kliewer (Institute for Pharmakology und Toxikology, University Clinic Jena, Jena, Germany):
“Cortico-Subcortical Dysconnectivity Following Opioid Administration Correlates with Analgesia in the Awake Mouse Brain”

09:45   Frederic Bihel and Frederic Simonin (Strasbourg, France):
“Characterization of a novel orally bioavailable NPFF receptor antagonist for the treatment of opioid-induced hyperalgesia and analgesic tolerance”

10:00   Lauren Brown (Nottingham, United Kingdom):
“Does receptor reserve underpin the improved therapeutic windows of opioid partial agonists?”

10:15   Dominique Massotte (Strasbourg, France):
“Mu-delta opioid heteromers and neuropathic pain”

10:30   Coffee break

11:00   Isabel Alves (Bordeaux, France):
“Impact of membrane lipid polyunsaturation on dopamine D2 receptor activation, signaling and internalisation”

11:15   Marjorie Damian (Montpellier, France):
“Gq protein peptidomimetics as allosteric modulators of the ghrelin receptor”

11:30   Farhad Dehkhoda (Brisbane, Australia):
“Constitutive activity of the ghrelin receptor provides a dominant second- messenger switch to re-code dopamine D2 receptor signal output”

11:45   Katia Befort (Strasbourg, France):
            “Regulation of the endocannabinoid system in binge eating disorder and obesity”

12:00   Martyna Szpakowska (Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg):
“Novel insights into the function and modulation of GPR182/ACKR5”

12:30   Lunch break and poster session

 

Session 3:

14:20   Group photo

14:30   Françoise Bachelerie (University Paris-Saclay, INSERM, Inflammation, Microbiome and Immunosurveillance, Orsay, France):
“The CXCL12 chemokine receptors CXCR4/ACKR3 in skin biology and interplay with papillomavirus”

15:15   Omolade Otun (Montpellier, France):
“Linking conformational landscape of Atypical Chemokine Receptor 3 (ACKR3) to ligand efficacy using Hydrogen/Deuterium Exchange Mass Spectrometry”

15:30   Christopher Schafer (Amsterdam, The Netherlands):
“Specific phosphorylation barcodes attenuate CCL25-mediated G protein coupling by CCR9”

15:45   Revvity (sponsor talk)

16:00   Coffee break

16:30   Rym Ben Boubaker (Montpellier, France):
“Activation dynamics of mGluR5 and Novel Positive Allosteric Modulator: A Computational Approach and Mechanistic Insights”

16:45   Luke Pattison (Cambridge, United Kingdom):
“A role for the proton-sensing GPCR, GPR65 in inflammatory joint pain”

17:00   Juliette Gourdon (Nouzilly, France):
“Spatio-temporal organization of LHCGR signalling is essential to regulate gonadal activity”

17:15   Martine Smit (Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands):
“Nanobody-based modulation of oncogenic chemokine receptors”

18:00   General assembly

18:30   Networking and dinner

 

Day 3 – Wednesday 10th of July 2024

Session 4:

09:00   Maria Marti-Solano (Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom):
“A multi-dimensional view of receptor – G protein coupling: learning from rare disease variants”

09:45   Isabella Maiellaro (Nottingham, United Kingdom):
“Leveraging Drosophila and AI for High-Throughput Studies of Inflammation-Induced Pain”

10:00   Shuguang Yuan (Basel, Switzerland):
“Advancing GPCR drug discovery via computational methods in an ultimately efficient way”

10:15   Coffee break

10:45   BMG LABTECH (sponsor talk)

11:00   Davide Calebiro (Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, Centre of Membrane Proteins and Receptors, Birmingham, United Kingdom):
“Untangling the GPCR puzzle with light: from arrestin to intracrine signalling”

11:45   Conclusion

12:00   End of meeting

 

 

Practical information :

How to get to Nottingham:

By train (international):

Eurostar to London St. Pancras

Eurostar trains arrive in London St. Pancras. Direct trains to Nottingham leave from this station.

 

By air:

East midlands airport

Directly connected to Nottingham, via skylink bus 1 hour, leaves every 20 minutes.

25-minute drive by car/taxi.

 

Birmingham airport

Connected to Nottingham via train, connecting in Birmingham New Street. Journey time 2 hours.

 

London Luton airport

Directly connected to Nottingham via train, 1 hour 40 minutes.

 

Other London airports

When flying into other London airports such as Stansted, Gatwick, or Heathrow, change trains in London. Trains to Nottingham leave from London St. Pancras.

Total journey time 3-4 hours.

 

Getting around Nottingham:

Both buses and trams can be paid for using contactless debit/credit cards.

 

Trams:
The tram is the most efficient option to travel from Nottingham Train Station to the University.

Toton Lane tram line runs from the centre of Nottingham and Nottingham Train Station to the University Park tram stop which is the closest to the conference venue and the Queen’s Medical Centre (QMC).

 

Buses:

NCT bus routes 34, 35, and 36 run the centre of Nottingham to Queen’s Medical Centre and University Park.

Hotels:

The Orchard, University of Nottingham Campus

Walking distance from the conference venue

https://nottinghamvenues.com/our-venues/orchard-hotel-restaurant

 

The Jubilee Hotel & Conferences

Located in the University of Nottingham Jubilee Campus (20-minute walk to the conference venue)

https://nottinghamvenues.com/bedrooms-accommodation/rooms-jubilee-hotel

 

Jury’s Inn/Leonardo hotel, Nottingham

Located next to Nottingham train station. Short walk from city centre.

Connected to the University of Nottingham and QMC via Toton Lane tram line.

https://www.leonardohotels.co.uk

 

Nottingham city centre Ibis

Located at Lace Market tram stop, city centre. Tram and bus connections to University.
https://all.accor.com/hotel/6160/index.en.shtml

 

Places to eat:

All include some vegan and gluten free options

https://www.baribericotapas.com

https://theangelmicrobrewery.co.uk

https://handandheartnottingham.co.uk

https://www.kayalrestaurant.com

https://www.castlerockbrewery.co.uk/pubs/canalhouse/  

(space for large groups and outdoor space)

Places to network:

https://www.31knotts.com

https://thekilpin.co.uk

https://www.pitcherandpiano.com/bars/nottingham (space for large groups)

https://wollatonhall.org.uk

https://www.nottinghamcity.gov.uk/HighfieldsPark


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