5th annual meeting of the IRN iGPCRnet in Barcelona

5th annual meeting of the IRN iGPCRnet in Barcelona - 7-9th July 2025

We are please to announce you that the next annual meeting of the IRN iGPCRnet will be held in Barcelona from the 7^th to the 9^th of July 2025.

The meeting will take place at University of Barcelona, University Zone, Faculty of pharmacy.

Campus Diagonal, Av. de Joan XXIII, 27-31, Distrito de Les Corts, 08028 Barcelona

Link to Google maps: https://maps.app.goo.gl/dDc6mf1SZ5qeX3CA7

The building with the accommodation rooms is right at the entrance of the Faculty:

Col·legi Major Penyafort - Montserrat

Av. Diagonal, 639, 641, Les Corts, 08028 Barcelona

Link to Google maps: https://maps.app.goo.gl/vKd1jYhUM1SErX2q6

DAY 1: July 7th
13.00h	Registration and Welcome
Session 1: Physiology of disease Chair: Amadeu Llebaria
14.00h	PT1: Ferdinando Nicoletti (Mediterranean Neurological Institute, IRCCS Neuromed, Pozzilli,, IT) The potential of photopharmacology for mGlu receptors: from mapping pain neuraxis to enhancing recovery after stroke
15.00h	OP01 Dayana Abboud (University of Liège, BE) GPR101 modulates body weight and food intake through specific population of neurons
15.15	OP02 Paula Álvarez-Montoya (University of Barcelona, ES) Gpr37 modulation of dopaminergic signaling: a molecular insight into schizophrenia pathophysiology
15.30h	Industrial short talks (sponsors)
16.00	Coffee break
Session 2: Context-dependent signalling Chair: Francisco Ciruela
16.30h	KT1: Meritxell Canals (University of Nottingham, UK) Delineating molecular and cellular determinants of μ-opioid receptor – β-arrestin2 interactions
17.15h	OC1: Mikel Garcia Marcos (Boston University, US) The secret life of G proteins
17.35h	OP03: Michela Di Michele (Institut des Biomolécules Max Mousseron, Montpellier, FR) Lipid environment modulates the scramblase activity of the ghrelin receptor
1.50h	OP04: Shanlin Rao (University of Cambridge, UK) A systems view of GPCR signalling pathway (re)wiring: Implications for pharmacology
18.05h	*Poster session 1* (PP001-PP040)
19.25h	Dinner
DAY2: July 8th
Session 3: Subcellular localised signalling and receptor internalisation Chair: Rebeca Díez-Alarcia
8.45h	OC2: Anna Aragay (Molecular Biology Institute of Barcelona - CSIC, ES) Gq regulation of organelle contacts and dynamics
9.05h	OP05: Raphael S. Haider (University of Nottingham, UK) Sketching subcellular maps of GPCR signaling complex formation and regulatory routes in the context of pain - are there pro-nociceptive arrestin conformational states?
9.20h	OP06 Julie Dam (Institut Cochin, Paris, FR) Correcting GLP-1R mutants from human carriers with a potent pharmacological chaperone
9.35h	OP07 Marta Cimadevila (Institut de Génomique Fonctionnelle, Montpellier, FR) Non canonical internalization properties of mGlu3
9.50h	OP08: Sergi Bravo (University of Bonn, DE) Nature’s Blueprint for Hyperefficient GPCR Internalisation : Leveraging Signaling Suppression and Receptor Endocytosis
10.05h	Coffee break
Session 4: GPCR Interacting proteins and oligomerisation Chair: Gemma Navarro
10.35h	KT2: Federico Mayor (Institute for Molecular Biology UAM-CSIC, Madrid, ES) GRK2 interactomes in cellular signalling and disease
11.20h	OP09: Céline Delaitre (University of Copenhagen, DK) Regulation of GPCR oligomerization revealed by high-throughput quantitative fluorescence imaging
11.35h	OP10 Marc Ciruela-Jardí (universitat Autònoma de Barcelona, ES) Distinct heteromeric partners modulate (S)-Methadone efficacy in MOR
11.50h	*Poster session 2* (PP041-PP80)
13.10h	Lunch

Session 5: New methodologies and molecular tools to study GPCR activity Chair: Xavier Rovira

14.10h KT2: Rob Leurs (Vrije Universiteit Amsterdam, NL)

Photopharmacology: towards new tools to unravel GPCR pharmacolog

14.55h

OP11 Robert B. Quast (Centre de Biologie Structurale, Montpellier, FR)

Dissecting the GPCR conformational landscape using biorthogonal click chemistries and multicolor single molecule FRET

15.10h OP12 Chia-Yang Lin (University of Nottingham, UK)

Ligand-directed labelling probes for covalent labelling of A₁ Adenosine Receptors

15.25 OP13 Iulia Bodnariuc (University of Utrecht , NL)

Methodology to study GPCRs in the native membrane environment: an in-cell solid-state NMR approach

15.40h Coffee break

Session 6: GPCR research in the industry Chair: TBD

16.10h KT4: Dominik Schelshorn and Anaëlle Dumazer (Neurosterix, Geneva, CH)

Beyond orthosteric binding in GPCR research: innovative assays for allosteric modulator drug discovery

16.55h OC3: Elodie Dupuis (Revvity, Codolet, FR)

New fluorescent detection modalities to investigate GPCRs signaling

17.15h OC6: Lawrence Welch (Nuclera, Cambridge, UK)

Producing assay-ready, purified, stable membrane proteins in under 48 hours

17.35h General Assembly iGPCRnet

18.05h Poster Session 3 (PP081-PP120)

19.25h Dinner

DAY 3: July 9th

Session 7: Molecular insights from structural biology and modelling Chair: Javier Garcia-Nafría

8.45h KT5: Jörg Standfuss (Paul Scherrer Institute, Villigen, CH)

Tracking ligand-GPCR interaction dynamics by time-resolved serial crystallography

9.30h OC7: Guillaume Lebon (Inst. Functional Genomics, Montpellier, FR)

Conformational; diversity on class C GPCR positive allosteric modulation

9.50h OP14: Jana Selent (Hosp. del Mar Medical Research Inst., Barcelona, ES)

Expanding the conformational space of the 3D GPCRome

10.05h OP15: Masha Niv (The Hebrew University of Jerusalem, IL)

Bitter Taste GPCRs in the Age of CryoEM and LLMs

10.20h OP16: Arisbel B. Gondin (Monash University, Parkville, AU)

Structure-guided design of allosteric modulators at the δ-Opioid Receptor

10.35 Coffee break

11.05h OC5: Maria Majellaro (Celtarys, Santiago de Compostela, ES)

A game-changing technology to Illuminate GPCR pharmacology: accelerating hit discovery & optimization

11.25h OC4: Martha Sommer (ISAR Bioscience, München, DE)

An Arresting Perspective on GPCR Signal Transduction

11.55h OP17: Pierre-André Lafon (Inst. Functional Genomics, Montpellier, FR)

Nanobody activator of mGlu2 receptor accelerates amyloidogenesis in Alzheimer’s disease

12:10h OP18: Pierre Couvineau (Inst. Functional Genomics, Montpellier, FR)

Functional selectivity of prototypical class A GPCRs : A journey from in silico to in vivo

12:25h PT2: Francisco Ciruela (University of Barcelona, ES)

In vivo GPCR Photopharmacology: Towards Therapeutics?

13.25h Conclusion and prizes

Sustainability Statement – Fund for Innovations in Sustainable Conferencing

Thanks to the support of the Fund for Innovations in Sustainable Conferencing from The Company of Biologists (https://www.biologists.com ), we have been able to implement a concrete measure to reduce the environmental impact of our event. Specifically, we offered a 20% discount on registration fees for participants who traveled by train from distances greater than 300 km, aiming to encourage the use of lower-carbon transport options.

We hope this initiative will inspire other events to adopt similar actions.

Many thanks to the sponsors for their support :