5th annual meeting of the IRN iGPCRnet in Barcelona - 7-9th July 2025

5th annual meeting of the IRN iGPCRnet in Barcelona - 7-9th July 2025


We are please to announce you that the next annual meeting of the IRN iGPCRnet will be held in Barcelona from the 7th to the 9th of July 2025.

The meeting will take place at University of Barcelona, University Zone, Faculty of pharmacy.

Campus Diagonal, Av. de Joan XXIII, 27-31, Distrito de Les Corts, 08028 Barcelona

Link to Google maps: https://maps.app.goo.gl/dDc6mf1SZ5qeX3CA7

 

The building with the accommodation rooms is right at the entrance of the Faculty:

Col·legi Major Penyafort - Montserrat

Av. Diagonal, 639, 641, Les Corts, 08028 Barcelona

Link to Google maps: https://maps.app.goo.gl/vKd1jYhUM1SErX2q6

 

DAY 1: July 7th

13.00h

Registration and Welcome

Session 1: Physiology of disease                                                            Chair: Amadeu Llebaria

14.00h

PT1:  Ferdinando Nicoletti (Mediterranean Neurological Institute, IRCCS Neuromed, Pozzilli,, IT)

The potential of photopharmacology for mGlu receptors: from mapping pain neuraxis to enhancing recovery after stroke

15.00h

OP01   Dayana Abboud (University of Liège, BE)

GPR101 modulates body weight and food intake through specific population of neurons

15.15

OP02   Paula Álvarez-Montoya (University of Barcelona, ES)
Gpr37 modulation of dopaminergic signaling: a molecular insight into schizophrenia pathophysiology

15.30h

Industrial short talks (sponsors)

16.00

Coffee break

Session 2: Context-dependent signalling                                                   Chair: Francisco Ciruela

16.30h

KT1:     Meritxell Canals (University of Nottingham, UK)
Delineating molecular and cellular determinants of μ-opioid receptor – β-arrestin2 interactions

17.15h

OC1:    Mikel Garcia Marcos (Boston University, US)

The secret life of G proteins

17.35h

OP03:  Michela Di Michele (Institut des Biomolécules Max Mousseron, Montpellier, FR)

Lipid environment modulates the scramblase activity of the ghrelin receptor

1.50h

OP04:  Shanlin Rao (University of Cambridge, UK)

A systems view of GPCR signalling pathway (re)wiring: Implications for pharmacology

18.05h

Poster session 1  (PP001-PP040)

19.25h

Dinner

 

DAY2: July 8th

Session 3: Subcellular localised signalling and receptor internalisation                 Chair: Rebeca Díez-Alarcia

8.45h

OC2:    Anna Aragay (Molecular Biology Institute of Barcelona - CSIC, ES)

Gq regulation of organelle contacts and dynamics

9.05h

OP05:   Raphael S. Haider (University of Nottingham, UK)

Sketching subcellular maps of GPCR signaling complex formation and regulatory routes in the context of pain - are there pro-nociceptive arrestin conformational states?

9.20h

OP06   Julie Dam (Institut Cochin, Paris, FR)
Correcting GLP-1R mutants from human carriers with a potent pharmacological chaperone

9.35h

OP07   Marta Cimadevila (Institut de Génomique Fonctionnelle, Montpellier, FR)

Non canonical internalization properties of mGlu3

9.50h

OP08:  Sergi Bravo (University of Bonn, DE)

Nature’s Blueprint for Hyperefficient GPCR Internalisation : Leveraging Signaling Suppression and Receptor Endocytosis

10.05h

Coffee break

Session 4: GPCR Interacting proteins and oligomerisation                                  Chair: Gemma Navarro

10.35h

KT2:      Federico Mayor (Institute for Molecular Biology UAM-CSIC, Madrid, ES)

GRK2 interactomes in cellular signalling and disease

11.20h

OP09:  Céline Delaitre (University of Copenhagen, DK)

Regulation of GPCR oligomerization revealed by high-throughput quantitative fluorescence imaging

11.35h

OP10   Marc Ciruela-Jardí (universitat Autònoma de Barcelona, ES)

Distinct heteromeric partners modulate (S)-Methadone efficacy in MOR

11.50h

Poster session 2 (PP041-PP80)

13.10h

Lunch

Session 5: New methodologies and molecular tools to study GPCR activity                          Chair: Xavier Rovira

14.10h

KT2:     Rob Leurs (Vrije Universiteit Amsterdam, NL)

Photopharmacology: towards new tools to unravel GPCR pharmacology

14.55h

OP11   Robert B. Quast (Centre de Biologie Structurale, Montpellier, FR)

Dissecting the GPCR conformational landscape using biorthogonal click chemistries and multicolor single molecule FRET

15.10h

OP12   Chia-Yang Lin (University of Nottingham, UK)

Ligand-directed labelling probes for covalent labelling of A1 Adenosine Receptors

15.25

OP13   Iulia Bodnariuc (University of Utrecht , NL)

Methodology to study GPCRs in the native membrane environment: an in-cell solid-state NMR approach

15.40h

Coffee break

Session 6: GPCR research in the industry                                                                 Chair: TBD

16.10h

KT4:     Dominik Schelshorn and Anaëlle Dumazer (Neurosterix, Geneva, CH)

Beyond orthosteric binding in GPCR research: innovative assays for allosteric modulator drug discovery

16.55h

OC3:    Elodie Dupuis (Revvity, Codolet, FR)

New fluorescent detection modalities to investigate GPCRs signaling

17.15h

OC4:    Martha Sommer (ISAR Bioscience, München, DE)

An Arresting Perspective on GPCR Signal Transduction

17.35h

OC5:    Maria Majellaro (Celtarys, Santiago de Compostela, ES)

A game-changing technology to Illuminate GPCR pharmacology: accelerating hit discovery & optimization

17.55h

OC6:    Lawrence Welch (Nuclera, Cambridge, UK)

Producing assay-ready, purified, stable membrane proteins in under 48 hours

18.15h

Poster Session 3 (PP081-PP120)

19.35h

Dinner

 

DAY 3: July 9th

Session 7: Molecular insights from structural biology and modelling                   Chair: Javier Garcia-Nafría

9.00h

KT5      Jörg Standfuss (Paul Scherrer Institute, Villigen, CH)

Tracking ligand-GPCR interaction dynamics by time-resolved serial crystallography

9.45h

OC7     Guillaume Lebon (Institut de Génomique Fonctionnelle, Montpellier, FR)

Conformational; diversity on class C GPCR positive allosteric modulation

10.05h

OP14   Jana Selent (Hospital del Mar Medical Research Institute, Barcelona, ES)

Expanding the conformational space of the 3D GPCRome

10.20h

OP15   Masha Niv (The Hebrew University of Jerusalem, IL)

Bitter Taste GPCRs in the Age of CryoEM and LLMs

10.35h

OP16   Arisbel Batista Gondin (Institute of Pharmaceutical Sciences, Monash University, Parkville, AU)
Structure-Guided Design of Allosteric Modulators at the Delta Opioid Receptor

10.50h

Coffee break

Session 8: Novel Therapies through targeting GPCRs                                            Chair: Ralf Jockers

11.20h

OP17   Pierre-André Lafon (Institut de Génomique Fonctionnelle, Montpellier, FR)

Nanobody activator of mGlu2 receptor accelerates amyloidogenesis in Alzheimer’s disease

11:35h

OP18   Pierre Couvineau (Institut de Génomique Fonctionnelle, Montpellier, FR)
Functional selectivity of prototypical class A GPCRs : A journey from in silico to in vivo

11:50h

PT2    Francisco Ciruela (University of Barcelona, ES)

In vivo GPCR Photopharmacology: Towards Therapeutics?

12.50h

i-GPCRnet Assembly, Conclusion, prizes

13.15h

End of meeting

 

Many thanks to the sponsors for their support :

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