5th annual meeting of the IRN iGPCRnet in Barcelona - 7-9th July 2025
We are please to announce you that the next annual meeting of the IRN iGPCRnet will be held in Barcelona from the 7th to the 9th of July 2025.
The meeting will take place at University of Barcelona, University Zone, Faculty of pharmacy.
Campus Diagonal, Av. de Joan XXIII, 27-31, Distrito de Les Corts, 08028 Barcelona
Link to Google maps: https://maps.app.goo.gl/dDc6mf1SZ5qeX3CA7
The building with the accommodation rooms is right at the entrance of the Faculty:
Col·legi Major Penyafort - Montserrat
Av. Diagonal, 639, 641, Les Corts, 08028 Barcelona
Link to Google maps: https://maps.app.goo.gl/vKd1jYhUM1SErX2q6
DAY 1: July 7th |
|
13.00h |
Registration and Welcome |
Session 1: Physiology of disease Chair: Amadeu Llebaria |
|
14.00h |
PT1: Ferdinando Nicoletti (Mediterranean Neurological Institute, IRCCS Neuromed, Pozzilli,, IT) The potential of photopharmacology for mGlu receptors: from mapping pain neuraxis to enhancing recovery after stroke |
15.00h |
OP01 Dayana Abboud (University of Liège, BE) GPR101 modulates body weight and food intake through specific population of neurons |
15.15 |
OP02 Paula Álvarez-Montoya (University of Barcelona, ES) |
15.30h |
Industrial short talks (sponsors) |
16.00 |
Coffee break |
Session 2: Context-dependent signalling Chair: Francisco Ciruela |
|
16.30h |
KT1: Meritxell Canals (University of Nottingham, UK) |
17.15h |
OC1: Mikel Garcia Marcos (Boston University, US) |
17.35h |
OP03: Michela Di Michele (Institut des Biomolécules Max Mousseron, Montpellier, FR) Lipid environment modulates the scramblase activity of the ghrelin receptor |
1.50h |
OP04: Shanlin Rao (University of Cambridge, UK) A systems view of GPCR signalling pathway (re)wiring: Implications for pharmacology |
18.05h |
Poster session 1 (PP001-PP040) |
19.25h |
Dinner |
DAY2: July 8th |
|
Session 3: Subcellular localised signalling and receptor internalisation Chair: Rebeca Díez-Alarcia |
|
8.45h |
OC2: Anna Aragay (Molecular Biology Institute of Barcelona - CSIC, ES) Gq regulation of organelle contacts and dynamics |
9.05h |
OP05: Raphael S. Haider (University of Nottingham, UK) Sketching subcellular maps of GPCR signaling complex formation and regulatory routes in the context of pain - are there pro-nociceptive arrestin conformational states? |
9.20h |
OP06 Julie Dam (Institut Cochin, Paris, FR) |
9.35h |
OP07 Marta Cimadevila (Institut de Génomique Fonctionnelle, Montpellier, FR) |
9.50h |
OP08: Sergi Bravo (University of Bonn, DE) Nature’s Blueprint for Hyperefficient GPCR Internalisation : Leveraging Signaling Suppression and Receptor Endocytosis |
10.05h |
Coffee break |
Session 4: GPCR Interacting proteins and oligomerisation Chair: Gemma Navarro |
|
10.35h |
KT2: Federico Mayor (Institute for Molecular Biology UAM-CSIC, Madrid, ES) |
11.20h |
OP09: Céline Delaitre (University of Copenhagen, DK) Regulation of GPCR oligomerization revealed by high-throughput quantitative fluorescence imaging |
11.35h |
OP10 Marc Ciruela-Jardí (universitat Autònoma de Barcelona, ES) Distinct heteromeric partners modulate (S)-Methadone efficacy in MOR |
11.50h |
Poster session 2 (PP041-PP80) |
13.10h |
Lunch |
Session 5: New methodologies and molecular tools to study GPCR activity Chair: Xavier Rovira |
|
14.10h |
KT2: Rob Leurs (Vrije Universiteit Amsterdam, NL) Photopharmacology: towards new tools to unravel GPCR pharmacology |
14.55h |
OP11 Robert B. Quast (Centre de Biologie Structurale, Montpellier, FR) Dissecting the GPCR conformational landscape using biorthogonal click chemistries and multicolor single molecule FRET |
15.10h |
OP12 Chia-Yang Lin (University of Nottingham, UK) Ligand-directed labelling probes for covalent labelling of A1 Adenosine Receptors |
15.25 |
OP13 Iulia Bodnariuc (University of Utrecht , NL) Methodology to study GPCRs in the native membrane environment: an in-cell solid-state NMR approach |
15.40h |
Coffee break |
Session 6: GPCR research in the industry Chair: TBD |
|
16.10h |
KT4: Dominik Schelshorn and Anaëlle Dumazer (Neurosterix, Geneva, CH) |
16.55h |
OC3: Elodie Dupuis (Revvity, Codolet, FR) New fluorescent detection modalities to investigate GPCRs signaling |
17.15h |
|
17.35h |
OC5: Maria Majellaro (Celtarys, Santiago de Compostela, ES) A game-changing technology to Illuminate GPCR pharmacology: accelerating hit discovery & optimization |
17.55h |
OC6: Lawrence Welch (Nuclera, Cambridge, UK) Producing assay-ready, purified, stable membrane proteins in under 48 hours |
18.15h |
Poster Session 3 (PP081-PP120) |
19.35h |
Dinner |
DAY 3: July 9th |
|
Session 7: Molecular insights from structural biology and modelling Chair: Javier Garcia-Nafría |
|
9.00h |
KT5 Jörg Standfuss (Paul Scherrer Institute, Villigen, CH) Tracking ligand-GPCR interaction dynamics by time-resolved serial crystallography |
9.45h |
OC7 Guillaume Lebon (Institut de Génomique Fonctionnelle, Montpellier, FR) Conformational; diversity on class C GPCR positive allosteric modulation |
10.05h |
OP14 Jana Selent (Hospital del Mar Medical Research Institute, Barcelona, ES) Expanding the conformational space of the 3D GPCRome |
10.20h |
OP15 Masha Niv (The Hebrew University of Jerusalem, IL) Bitter Taste GPCRs in the Age of CryoEM and LLMs |
10.35h |
OP16 Arisbel Batista Gondin (Institute of Pharmaceutical Sciences, Monash University, Parkville, AU) |
10.50h |
Coffee break |
Session 8: Novel Therapies through targeting GPCRs Chair: Ralf Jockers |
|
11.20h |
OP17 Pierre-André Lafon (Institut de Génomique Fonctionnelle, Montpellier, FR) Nanobody activator of mGlu2 receptor accelerates amyloidogenesis in Alzheimer’s disease |
11:35h |
OP18 Pierre Couvineau (Institut de Génomique Fonctionnelle, Montpellier, FR) |
11:50h |
PT2 Francisco Ciruela (University of Barcelona, ES) In vivo GPCR Photopharmacology: Towards Therapeutics? |
12.50h |
i-GPCRnet Assembly, Conclusion, prizes |
13.15h |
End of meeting |
Many thanks to the sponsors for their support :
.