November 30 -December 3, 2021: i-GPCRnet International (Online) Meeting
PROGRAM OF THE MEETING
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All times are in CET
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Day 1: Tuesday, November 30, 2021
To visualize the Flash Talks we suggest you to click on the image above.
14.00-14.20: Introduction: Ralf Jockers/ Martin Lohse/ Stephen Hill
SESSION 1: Structural dynamics of GPCR activation and signaling
(Chairs: Andreas Bock and Chanjuan Xu)
14.20-14.40: Jianfeng Liu (Huazhong University of Science and Technology, China)
Activation mechanism of neurotransmitter GPCR
14.40-15.00: Fei Xu (ShanghaiTech University, China)
A self-activated orphan GPCR
15.00-15.20: Chris Tate (MRC Laboratory of Molecular Biology, UK)
Structure and activation of a Class D GPCR
15.20-15.40: Tracy Handel (University of California, San Diego, US)
Structure and activation mechanisms of G protein-coupled and atypical chemokine receptors
15.40-15.55: Discussion
16.00-16.20: Flash presentations 1
SESSION 2: Computational Biology in GPCR Research
(Chairs: Nicolas Floquet and Marcel Bermudez)
16.30-16.50: Masha Niv (The Hebrew University, Israel)
Molecular match-making for taste GPCRs
16.50-17.10: Patrick Barth (Swiss Federal Institute of Technology, Switzerland)
Uncovering and reprogramming GPCR signaling by computational design
17.10-17.30: Peter Kolb (Philipps-University Marburg, Germany)
The pocketome of GPCRs reveals previously untargeted allosteric sites
17.30-17.50: Xavier Deupi (Paul Scherrer Institute, Switzerland)
Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
17.50-18.05: Discussion
18.10-18.30: Flash Presentations 2
18.40-19.30: Keynote Lecture 1
(Chair: Martin Lohse)
Jin Zhang (University of California, San Diego, USA)
Illuminating the Biochemical Activity Architecture of the Cell
Day 2: Wednesday, December 1, 2021
All times are in CET
SESSION 3: Compartmentalisation of GPCR Signaling
(Chairs: Andreas Bock and Charlotte Kayser)
14.00-14.20: Viacheslav Nikolaev (University Medical Center Hamburg, Germany)
Nanodomains of cardiac beta-adrenoceptor/cAMP signalling visualised by live cell imaging
14.20-14.40: Manuela Zaccolo (University of Oxford, Oxford, UK)
Mapping beta-adrenergic nanodomains in the heart using proteomics
14.40-15.00: Meritxell Canals (University of Nottingham, Nottingham, UK)
Modulation of the mu-opioid receptor signalling
15.00-15.20: John Scott (University of Washington, Seattle, USA)
Exploring and exploiting the spatial constraints of cAMP signaling
15.20-15.35: Discussion
15.40-16.00: Flash presentations 3
SESSION 4: GPCR Physiology and Pathology
(Chairs: Françoise Bachelerie and Charlotte Kayser)
16.10-16.30: Aylin Hanyaloglu (Imperial College London, UK)
Endosomal programming of gonadotrophin hormone receptor signalling; new pharmacological targets and models of disease
16.30-16.50: Torsten Schöneberg (University of Leipzig, Germany)
GPCR dysfunctions as causes of human pathologies
16.50-17.10 : Julie Perroy (Institut de Génomique Fonctionnelle, France)
Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice
17.10-17.30: Paul Insel (University of California San Diego, USA)
GPCRs as novel therapeutic targets in cancers
17.30-17.45: Discussion
17.50-18.10: Flash Presentations 4
18.20-19.10: Keynote Lecture 2
(Chair: Stephen Hill)
Jean-Philippe Pin (Institut de Génomique Fonctionnelle, FR)
Structure and dynamics of the asymmetric activation of class C GPCR dimers
Day 3: Thursday, December 2, 2021
All times are in CET
SESSION 5: Up and Coming Technologies to Target GPCRs
(Chairs: Laura Kilpatrick and Laura Lemel)
14.00-14.20: Carl White (University of Western Australia, Australia)
CRISPR-tagging of chemokine receptors with Nanoluciferase to probe endogenous receptor function
14.20-14.40: Eleonora Comeo (University of Nottingham, UK)
Illuminating the Life of the Adenosine Receptors: Development and Application of Fluorescent Probes for the Study of the Adenosine A1 Receptor in Living Cells
14.40-15.00: Mark Wheatley (Coventry University, UK)
GPCR-Lipid Particles: the shape of things to come
15.00-15.20: Mikel Garcia-Marcos (Boston University, USA)
Versatile optical biosensors of heterotrimeric G protein activity
15.20-15.35: Discussion
15.40-16.00: Flash Presentations 5
SESSION 6: GPCR Crosstalk with Microbe
(Chair: Françoise Bachelerie)
16.10-16.30: Tim Lämmermann (Max Planck Institute of Immunobiology and Epigenetics, Germany)
GPCR desensitization self-limits neutrophil swarms and control bacterial containment
16.30-16.50: Martine Smit (Vrije Universiteit Amsterdam, Netherlands)
Modulating viral GPCR function by nanobodies
16.50-17.10 : Nathalie Vergnolle (INSERM U1220, France)
Thrombin at the crossroads of GPCR and microbiota signalling
17.10-17.30: Stefano Marullo (Institut Cochin, France)
Meningococcal/beta2 adrenergic interactions
17.30-17.45: Discussion
17.50-18.10: Flash Presentations 6
No recording available
18.20-19.10: Keynote Lecture 3 (Chair: Ralf Jockers )
Stefan Offermanns (Max Planck Institute for Heart and Lung Research, Germany)
Novel GPCR functions in the cardiovascular and metabolic system
Day 4: Friday, December 3, 2021
All times are in CET
SESSION 7: Frizzled and adhesion GPCRs
(Chairs: Laura Kilpatrick and Denis Servent)
14.00-14.20: Ines Liebscher (University of Leipzig, Germany)
Translating the force – pharmacology and physiology of mechano-sensing adhesion GPCRs
14.20-14.40: JinPeng Sun (Shandong University School of Medicine, China)
Structural basis of recognizing steroid hormones by aGPCRs
14.40-15.00: Hannes Schihada (Karolinska Institute, Sweden)
Dissecting WNT-induced Frizzled activation and signalling with conformational sensors
15.00-15.20: Xianhua Piao (University of California San Francisco, USA)
GPCR-dependent Microglia Function in Development
15.20-15.35: Discussion
15.40-16.00: Flash Presentations 7
SESSION 8: GPCRs and Drug Development
(Chairs: Julie Sanchez and Denis Servent)
16.10-16.30: Mark Soave (University of Nottingham, UK)
Monitoring Allosteric Interactions at CXCR4 using NanoBiT-conjugated Nanobodies
16.30-17.00: Sadashiva S Karnik (Cleveland Clinic Lerner College of Medicine, USA)
A Novel Allosteric Pocket in the Major Receptor for Angiotensin II
17.00-17.20: Christa Müller (University of Bonn, Germany)
Development of novel ligands for purinergic G protein-coupled receptors
17.20-17.40: Eric Trinquet (Perkin Elmer, France)
Innovative Solutions to investigate GPCR function & signaling
17.40-18.00: Discussion
18.10-19.00: Keynote Lecture 4
(Chair: Phillipe Marin)
Laura Bohn (The Scripps Research Institute, USA)
Imparting biased agonism and allostery at the mu opioid receptor to improve the therapeutic index
19.00-19.30: Awards & Conclusions
(Chairs: Stephen Hill & Xavier Iturrioz)
The i-GPCRnet meeting organizing committee
Françoise Bachelerie (Université Paris-Saclay, France)
Denis Servent (CEA, Université Paris-Saclay, France)
Andreas Bock (MDC Berlin, Germany)
Charlotte Kayser (MDC Berlin, Germany)
Laura Kilpatrick (University of Nottingham, UK)
Laura Lemel (University of Nottingham, UK)
Julie Sanchez (University of Nottingham, UK)
Chanjuan Xu (Huazhong University of Science and Technology, China)
Pin Yi (Huazhong University of Science and Technology, China)
Xavier Iturrioz (CEA, France)