Save the date: 4th IRN i-GPCRnet meeting from July 8th to 10th, 2024 in Nottingham
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4th IRN i-GPCRnet Annual Meeting Programme
4th IRN i-GPCRnet Annual Meeting Programme
Day 1 – Monday 8th of July 2024
12:00 Opening and registration
14:15 Introduction
Session 1:
14:30 Carsten Hoffmann (Institute for Molecular Cell Biology, CMB – Center for Molecular Biomedicine, University Clinic Jena, Jena, Germany):
“Novel insights into GPCR regulation by using GRK-KO cells”
15:15 Maria Tindara Ignazzitto (Barcelona, Spain):
“Photoswitching azobenzenes to reversibly control β-adrenergic receptors with light”
15:30 Yair Ben-Chaim (Ra’anana, Israel):
“Voltage dependence of G protein coupled receptors”
15:45 Laura Klement (Jena, Germany):
“Targeting cellular kinases to prevent Influenza A virus infection utilizing encapsulated
kinase inhibitors”
16:00 Coffee break
16:30 Promega (sponsor talk)
16:45 Cyril Goudet (Montpellier, France):
“Optical control of adenosine A2A receptor using istradefylline photosensitivity”
17:00 Amod Godbole (Jena, Germany):
“The molecular basis for GRK/arrestin-mediated regulation of adenosine A1 receptor”
17:15 Ana Novak (Orléans, France):
“Identification and characterization of nanobodies targeting serotonin 5-HT7 receptor
for application in GPCR Drug Discovery”
17:30 Chris Tate (MRC Laboratory of Molecular Biology, Cambridge, United Kingdom):
“GPCR dimerisation: insights from cryo-EM structures of the yeast pheromone receptor Ste2”
18:15 Poster session and dinner
Day 2 – Tuesday 9th of July 2024
Session 2:
09:00 Andrea Kliewer (Institute for Pharmakology und Toxikology, University Clinic Jena, Jena, Germany):
“Cortico-Subcortical Dysconnectivity Following Opioid Administration Correlates with Analgesia in the Awake Mouse Brain”
09:45 Frederic Bihel and Frederic Simonin (Strasbourg, France):
“Characterization of a novel orally bioavailable NPFF receptor antagonist for the treatment of opioid-induced hyperalgesia and analgesic tolerance”
10:00 Lauren Brown (Nottingham, United Kingdom):
“Does receptor reserve underpin the improved therapeutic windows of opioid partial agonists?”
10:15 Dominique Massotte (Strasbourg, France):
“Mu-delta opioid heteromers and neuropathic pain”
10:30 Coffee break
11:00 Isabel Alves (Bordeaux, France):
“Impact of membrane lipid polyunsaturation on dopamine D2 receptor activation, signaling and internalisation”
11:15 Marjorie Damian (Montpellier, France):
“Gq protein peptidomimetics as allosteric modulators of the ghrelin receptor”
11:30 Farhad Dehkhoda (Brisbane, Australia):
“Constitutive activity of the ghrelin receptor provides a dominant second- messenger switch to re-code dopamine D2 receptor signal output”
11:45 Katia Befort (Strasbourg, France):
“Regulation of the endocannabinoid system in binge eating disorder and obesity”
12:00 Martyna Szpakowska (Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg):
“Novel insights into the function and modulation of GPR182/ACKR5”
12:30 Lunch break and poster session
Session 3:
14:20 Group photo
14:30 Françoise Bachelerie (University Paris-Saclay, INSERM, Inflammation, Microbiome and Immunosurveillance, Orsay, France):
“The CXCL12 chemokine receptors CXCR4/ACKR3 in skin biology and interplay with papillomavirus”
15:15 Omolade Otun (Montpellier, France):
“Linking conformational landscape of Atypical Chemokine Receptor 3 (ACKR3) to ligand efficacy using Hydrogen/Deuterium Exchange Mass Spectrometry”
15:30 Christopher Schafer (Amsterdam, The Netherlands):
“Specific phosphorylation barcodes attenuate CCL25-mediated G protein coupling by CCR9”
15:45 Revvity (sponsor talk)
16:00 Coffee break
16:30 Rym Ben Boubaker (Montpellier, France):
“Activation dynamics of mGluR5 and Novel Positive Allosteric Modulator: A Computational Approach and Mechanistic Insights”
16:45 Luke Pattison (Cambridge, United Kingdom):
“A role for the proton-sensing GPCR, GPR65 in inflammatory joint pain”
17:00 Juliette Gourdon (Nouzilly, France):
“Spatio-temporal organization of LHCGR signalling is essential to regulate gonadal activity”
17:15 Martine Smit (Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands):
“Nanobody-based modulation of oncogenic chemokine receptors”
18:00 General assembly
18:30 Networking and dinner
Day 3 – Wednesday 10th of July 2024
Session 4:
09:00 Maria Marti-Solano (Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom):
“A multi-dimensional view of receptor – G protein coupling: learning from rare disease variants”
09:45 Isabella Maiellaro (Nottingham, United Kingdom):
“Leveraging Drosophila and AI for High-Throughput Studies of Inflammation-Induced Pain”
10:00 Shuguang Yuan (Basel, Switzerland):
“Advancing GPCR drug discovery via computational methods in an ultimately efficient way”
10:15 Coffee break
10:45 BMG LABTECH (sponsor talk)
11:00 Davide Calebiro (Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, Centre of Membrane Proteins and Receptors, Birmingham, United Kingdom):
“Untangling the GPCR puzzle with light: from arrestin to intracrine signalling”
11:45 Conclusion
12:00 End of meeting
Organizing Committee:
Stephen Hill (University of Nottingham)
Ralf Jockers (Institut Cochin, Paris)
Meritxell Canals (University of Nottingham)
Robert Lane (University of Nottingham)
Jeanette Woolard (University of Nottingham)
Stephen Briddon (University of Nottingham)
Julie Sanchez (University of Nottingham)
Raphael Haider (University of Nottingham)
Simon Platt (University of Nottingham)
Laura Kilpatrick (University of Nottingham)
Chloe Peach (University of Nottingham)
Clare Harwood (University of Nottingham)
Eddy Wragg (University of Nottingham)
Xavier Iturrioz (INSERM CEA, Gif-sur-Yvette)
Practical information :
How to get to Nottingham:
By train (international):
Eurostar to London St. Pancras
Eurostar trains arrive in London St. Pancras. Direct trains to Nottingham leave from this station.
By air:
East midlands airport
Directly connected to Nottingham, via skylink bus 1 hour, leaves every 20 minutes.
25-minute drive by car/taxi.
Birmingham airport
Connected to Nottingham via train, connecting in Birmingham New Street. Journey time 2 hours.
London Luton airport
Directly connected to Nottingham via train, 1 hour 40 minutes.
Other London airports
When flying into other London airports such as Stansted, Gatwick, or Heathrow, change trains in London. Trains to Nottingham leave from London St. Pancras.
Total journey time 3-4 hours.
Getting around Nottingham:
Both buses and trams can be paid for using contactless debit/credit cards.
Trams:
The tram is the most efficient option to travel from Nottingham Train Station to the University.
Toton Lane tram line runs from the centre of Nottingham and Nottingham Train Station to the University Park tram stop which is the closest to the conference venue and the Queen’s Medical Centre (QMC).
Buses:
NCT bus routes 34, 35, and 36 run the centre of Nottingham to Queen’s Medical Centre and University Park.
Hotels:
The Orchard, University of Nottingham Campus
Walking distance from the conference venue
https://nottinghamvenues.com/our-venues/orchard-hotel-restaurant
The Jubilee Hotel & Conferences
Located in the University of Nottingham Jubilee Campus (20-minute walk to the conference venue)
https://nottinghamvenues.com/bedrooms-accommodation/rooms-jubilee-hotel
Jury’s Inn/Leonardo hotel, Nottingham
Located next to Nottingham train station. Short walk from city centre.
Connected to the University of Nottingham and QMC via Toton Lane tram line.
https://www.leonardohotels.co.uk
Nottingham city centre Ibis
Located at Lace Market tram stop, city centre. Tram and bus connections to University.
https://all.accor.com/hotel/6160/index.en.shtml
Places to eat:
All include some vegan and gluten free options
https://www.baribericotapas.com
https://theangelmicrobrewery.co.uk
https://handandheartnottingham.co.uk
https://www.kayalrestaurant.com
https://www.castlerockbrewery.co.uk/pubs/canalhouse/
(space for large groups and outdoor space)
Places to network:
https://www.pitcherandpiano.com/bars/nottingham (space for large groups)