5th annual meeting of the IRN iGPCRnet in Barcelona - 7-9th July 2025

DAY 1: July 7th

14.00h

Registration and Welcome

Session 1: Physiology of disease                                                           Chair: Amadeu Llebaria

14.30h

PT1:  Ferdinando Nicoletti (Mediterranean Neurological Institute, IRCCS Neuromed, Pozzilli,, IT)

The potential of photopharmacology for mGlu receptors: from mapping pain neuraxis to enhancing recovery after stroke

15.30h

OP1    Dayana Abboud (University of Liège, BE)

GPR101 modulates body weight and food intake through specific population of neurons

15.45h

OP2     Paula Álvarez-Montoya (University of Barcelona, ES)
Gpr37 modulation of dopaminergic signaling: a molecular insight into schizophrenia pathophysiology

16.15

Coffee break

Session 2: Context-dependent signalling                                                  Chair: Francisco Ciruela

16.45h

KT1:     Meritxell Canals (University of Nottingham, UK)
Delineating molecular and cellular determinants of μ-opioid receptor – β-arrestin2 interactions

17.30h

OC1:    Mikel Garcia Marcos (Boston University, US)

The secret life of G proteins

17.50h

OP3:    Michela Di Michele (Institut des Biomolécules Max Mousseron, Montpellier, FR)

Lipid environment modulates the scramblase activity of the ghrelin receptor

18.05h

OP4:   Shanlin Rao (University of Cambridge, UK)

A systems view of GPCR signalling pathway (re)wiring: Implications for pharmacology

18.20h

Poster session 1

19.30h

Dinner

DAY2: July 8th

Session 3: Subcellular localised signalling                                              Chair: Rebeca Díez-Alarcia

9.00h

KT2:     Luigi Bellocchio (Neurocentre Magendie, Bordeaux, FR)

Mitochondrial GPCR signaling as a potential therapeutic target

9.45h

OC2:    Anna Aragay (Molecular Biology Institute of Barcelona - CSIC, ES)

Gq regulation of organelle contacts and dynamics

10.05h

OP5:    Raphael S. Haider (University of Nottingham, UK)

Sketching subcellular maps of GPCR signaling complex formation and regulatory routes in the context of pain - are there pro-nociceptive arrestin conformational states?

10.20h

OP6:   Sergi Bravo (University of Bonn, DE)

Nature’s Blueprint for Hyperefficient GPCR Internalisation : Leveraging Signaling Suppression and Receptor Endocytosis

10.35h

Coffee break

Session 4: GPCR Interacting proteins and oligomerisation                                Chair: Gemma Navarro

11.05h

KT3:      Federico Mayor (Institute for Molecular Biology UAM-CSIC, Madrid, ES)

GRK2 interactomes in cellular signalling and disease

11.50h

OP7    Marta Cimadevila (Institut de Génomique Fonctionnelle, Montpellier, FR)

Non canonical internalization properties of mGlu3

12.05h

OP8:   Céline Delaitre (University of Copenhagen, DK)

Regulation of GPCR oligomerization revealed by high-throughput quantitative fluorescence imaging

12.20h

OP9    Marc Ciruela-Jardí (universitat Autònoma de Barcelona, ES)

Distinct heteromeric partners modulate (S)-Methadone efficacy in MOR

12.35h

Poster Session 2

13.45h

Lunch

Session 5: New methodologies and molecular tools to study GPCR activity                        Chair: Xavier Rovira

14.45h

KT4:     Rob Leurs (Vrije Universiteit Amsterdam, NL)

Photopharmacology: towards new tools to unravel GPCR pharmacology

15.30h

OP10   Chia-Yang Lin (University of Nottingham, UK)

Ligand-directed labelling probes for covalent labelling of A₁ Adenosine Receptors

15.45h

OP11   Iulia Bodnariuc (University of Utrecht , NL)

Methodology to study GPCRs in the native membrane environment: an in-cell solid-state NMR approach

16.00h

Coffee break

Session 6: GPCR research in the industry                                                 Chair: Gebhard Schertler

6.30h

KT5:     Dominik Schelshorn and Anaëlle Dumazer (Neurosterix, Geneva, CH)

Beyond orthosteric binding in GPCR research: innovative assays for allosteric modulator drug discovery

17.15h

OC3:    Elodie Dupuis (Revvity, Codolet, FR)

New fluorescent detection modalities to investigate GPCRs signaling

17.35h

OC4:    Martha Sommer (ISAR Bioscience, München, DE)

An Arresting Perspective on GPCR Signal Transduction

17.55h

OC5:    Maria Majellaro (Celtarys, Santiago de Compostela, ES)

A game-changing technology to Illuminate GPCR pharmacology: accelerating hit discovery & optimization

18.15h

OC6:    Melissa Balzano (Nuclera, Cambridge, UK)

Producing assay-ready, purified, stable membrane proteins in under 48 hours

18.35h

Industrial short talks (sponsors)

19.05h

i-GPCRnet Assembly

19.30h

Dinner

DAY 3: July 9th

Session 7: Molecular insights from structural biology and modelling                  Chair: Javier Garcia-Nafría

9.00h

KT6      Jörg Standfuss (Paul Scherrer Institute, Villigen, CH)

Tracking ligand-GPCR interaction dynamics by time-resolved serial crystallography

9.45h

OC7    Guillaume Le Bon Institut de Génomique Fonctionnelle, Montpellier, FR)

Conformational; diversity on class C GPCR positive allosteric modulation

10.05h

OP12   Robert B. Quast (Centre de Biologie Structurale, Montpellier, FR)

Dissecting the GPCR conformational landscape using biorthogonal click chemistries and multicolor single molecule FRET

10.20h

OP13   Jana Selent (Hospital del Mar Medical Research Institute, Barcelona, ES)

Expanding the conformational space of the 3D GPCRome

10.35h

OP14   Masha Niv (The Hebrew University of Jerusalem, IL)

Bitter Taste GPCRs in the Age of CryoEM and LLMs

10.50h

Coffee break

Session 8: Novel Therapies through targeting GPCRs                                           Chair: Ralf Jockers

11.15h

OP15   Pierre-André Lafon (Huazhong University of Science and Technology, Wuhan, CN)

Nanobody activator of mGlu₂ receptor accelerates amyloidogenesis in Alzheimer’s disease

11:30h

OP16   Pierre Couvineau (Institut de Génomique Fonctionnelle, Montpellier, FR)
Functional selectivity of prototypical class A GPCRs : A journey from in silico to in vivo

11:45h

PT2    Francisco Ciruela (University of Barcelona, ES)

In vivo GPCR Photopharmacology: Towards Therapeutics?

12.45h

Conclusion, prizes

13.00h

End of meeting