November 30 -December 3, 2021: i-GPCRnet International (Online) Meeting

November 30 -December 3, 2021: i-GPCRnet International (Online) Meeting


 

PROGRAM OF THE MEETING

for pdf click here

All times are in CET

 

Click on the image below to see the Poster Room at any time after the meeting (use the Passcode of the meeting)

Click on the image to see the Poster Room (use the Passcode of the meeting)

 


Day 1: Tuesday, November 30, 2021  

 To visualize the Flash Talks we suggest you to click on the image above.

 

14.00-14.20: Introduction: Ralf Jockers/ Martin Lohse/ Stephen Hill

     

SESSION 1:     Structural dynamics of GPCR activation and signaling 

(Chairs: Andreas Bock and Chanjuan Xu)

 

14.20-14.40:       Jianfeng Liu (Huazhong University of Science and Technology, China)

Activation mechanism of neurotransmitter GPCR 

 

14.40-15.00:        Fei Xu (ShanghaiTech University, China)

A self-activated orphan GPCR

 

15.00-15.20:      Chris Tate (MRC Laboratory of Molecular Biology, UK)

Structure and activation of a Class D GPCR

 

15.20-15.40:       Tracy Handel (University of California, San Diego, US)

Structure and activation mechanisms of G protein-coupled and atypical chemokine receptors

 

15.40-15.55:       Discussion

 

16.00-16.20:      Flash presentations 1

 

 

SESSION 2:     Computational Biology in GPCR Research 

(Chairs: Nicolas Floquet and Marcel Bermudez)

 

16.30-16.50:       Masha Niv (The Hebrew University, Israel)

Molecular match-making for taste GPCRs

 

16.50-17.10:       Patrick Barth (Swiss Federal Institute of Technology, Switzerland)

Uncovering and reprogramming GPCR signaling by computational design

 

17.10-17.30:       Peter Kolb (Philipps-University Marburg, Germany)

The pocketome of GPCRs reveals previously untargeted allosteric sites

 

17.30-17.50:        Xavier Deupi (Paul Scherrer Institute, Switzerland)

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

 

17.50-18.05:      Discussion 

 

18.10-18.30:       Flash Presentations 2

 

 

 

 

18.40-19.30:      Keynote Lecture 1

(Chair: Martin Lohse)

Jin Zhang (University of California, San Diego, USA)

Illuminating the Biochemical Activity Architecture of the Cell


Day 2: Wednesday, December 1, 2021

All times are in CET

SESSION 3:     Compartmentalisation of GPCR Signaling 

(Chairs: Andreas Bock and  Charlotte Kayser)

 

14.00-14.20:       Viacheslav Nikolaev (University Medical Center Hamburg, Germany)

Nanodomains of cardiac beta-adrenoceptor/cAMP signalling visualised by live cell imaging

 

14.20-14.40:       Manuela Zaccolo (University of Oxford, Oxford, UK)

Mapping beta-adrenergic nanodomains in the heart using proteomics

 

14.40-15.00:      Meritxell Canals (University of Nottingham, Nottingham, UK)

Modulation of the mu-opioid receptor signalling

 

15.00-15.20:      John Scott (University of Washington, Seattle, USA)

Exploring and exploiting the spatial constraints of cAMP signaling

 

15.20-15.35:       Discussion

 

15.40-16.00:       Flash presentations 3 

 

 

SESSION 4:     GPCR Physiology and Pathology 

(Chairs: Françoise Bachelerie and Charlotte Kayser)

16.10-16.30:       Aylin Hanyaloglu (Imperial College London, UK)

Endosomal programming of gonadotrophin hormone receptor signalling; new pharmacological targets and models of disease

 

16.30-16.50:       Torsten Schöneberg (University of Leipzig, Germany)

GPCR dysfunctions as causes of human pathologies

 

16.50-17.10 :      Julie Perroy (Institut de Génomique Fonctionnelle, France)

Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice

 

17.10-17.30:       Paul Insel (University of California San Diego, USA)

GPCRs as novel therapeutic targets in cancers

 

17.30-17.45:       Discussion

 

17.50-18.10:      Flash Presentations 4

 

 

18.20-19.10:       Keynote Lecture 2

(Chair:  Stephen Hill)  

Jean-Philippe Pin (Institut de Génomique Fonctionnelle, FR)

Structure and dynamics of the asymmetric activation of class C GPCR dimers

 


Day 3: Thursday, December 2, 2021

All times are in CET

 

SESSION 5:   Up and Coming Technologies to Target GPCRs 

(Chairs: Laura Kilpatrick and Laura Lemel)

 

 

14.00-14.20:       Carl White (University of Western Australia, Australia) 

CRISPR-tagging of chemokine receptors with Nanoluciferase to probe endogenous receptor function

 

14.20-14.40:       Eleonora Comeo (University of Nottingham, UK) 

Illuminating the Life of the Adenosine Receptors: Development and Application of Fluorescent Probes for the Study of the Adenosine A1 Receptor in Living Cells

 

14.40-15.00:       Mark Wheatley (Coventry University, UK)

GPCR-Lipid Particles: the shape of things to come

 

15.00-15.20:       Mikel Garcia-Marcos (Boston University, USA)

Versatile optical biosensors of heterotrimeric G protein activity

 

15.20-15.35:       Discussion

 

15.40-16.00:       Flash Presentations 5 

 

 

SESSION 6:   GPCR Crosstalk with Microbe 

(Chair: Françoise Bachelerie)

 

16.10-16.30:       Tim Lämmermann (Max Planck Institute of Immunobiology and Epigenetics, Germany)

GPCR desensitization self-limits neutrophil swarms and control bacterial containment

 

16.30-16.50:        Martine Smit (Vrije Universiteit Amsterdam, Netherlands)

Modulating viral GPCR function by nanobodies 

 

16.50-17.10 :       Nathalie Vergnolle (INSERM U1220, France)

Thrombin at the crossroads of GPCR and microbiota signalling 

 

17.10-17.30:       Stefano Marullo (Institut Cochin, France)

Meningococcal/beta2 adrenergic interactions

 

17.30-17.45:       Discussion 

 

17.50-18.10:  Flash Presentations 6 

 

No recording available

18.20-19.10:  Keynote Lecture 3 (Chair:  Ralf Jockers )

Stefan Offermanns (Max Planck Institute for Heart and Lung Research, Germany)

Novel GPCR functions in the cardiovascular and metabolic system

 


Day 4: Friday, December 3, 2021

All times are in CET

 

SESSION 7:      Frizzled and adhesion GPCRs 

(Chairs: Laura Kilpatrick and Denis Servent)

 

14.00-14.20:       Ines Liebscher (University of Leipzig, Germany) 

Translating the force – pharmacology and physiology of mechano-sensing adhesion GPCRs

 

14.20-14.40:       JinPeng Sun (Shandong University School of Medicine, China)

Structural basis of recognizing steroid hormones by aGPCRs 

 

14.40-15.00:       Hannes Schihada (Karolinska Institute, Sweden)

Dissecting WNT-induced Frizzled activation and signalling with conformational sensors

 

15.00-15.20:       Xianhua Piao (University of California San Francisco, USA) 

GPCR-dependent Microglia Function in Development

 

15.20-15.35:       Discussion

 

15.40-16.00:       Flash Presentations 7  

 

 

SESSION 8:     GPCRs and Drug Development

(Chairs: Julie Sanchez and Denis Servent)

 

 

16.10-16.30:       Mark Soave (University of Nottingham, UK)

Monitoring Allosteric Interactions at CXCR4 using NanoBiT-conjugated Nanobodies

 

16.30-17.00:       Sadashiva S Karnik (Cleveland Clinic Lerner College of Medicine, USA)

A Novel Allosteric Pocket in the Major Receptor for Angiotensin II

 

17.00-17.20:       Christa Müller (University of Bonn, Germany)

Development of novel ligands for purinergic G protein-coupled receptors

 

17.20-17.40:       Eric Trinquet (Perkin Elmer, France)

Innovative Solutions to investigate GPCR function & signaling 

 

17.40-18.00:       Discussion

 

 

18.10-19.00:      Keynote Lecture 4

(Chair: Phillipe Marin)  

Laura Bohn (The Scripps Research Institute, USA)

Imparting biased agonism and allostery at the mu opioid receptor to improve the therapeutic index

 

19.00-19.30:       Awards & Conclusions 

(Chairs: Stephen Hill & Xavier Iturrioz)

 


The i-GPCRnet meeting organizing committee

Françoise Bachelerie (Université Paris-Saclay, France)

Denis Servent (CEA, Université Paris-Saclay, France)

Andreas Bock (MDC Berlin, Germany)

Charlotte Kayser (MDC Berlin, Germany)

Laura Kilpatrick (University of Nottingham, UK)

Laura Lemel (University of Nottingham, UK)

Julie Sanchez (University of Nottingham, UK)

Chanjuan Xu (Huazhong University of Science and Technology, China)

Pin Yi (Huazhong University of Science and Technology, China)


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